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    Viagra and cancer


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    A small, daily dose of Viagra significantly reduces colorectal cancer risk in an animal model that is genetically predetermined to have the third leading cause of cancer death, scientists report. Medical College of Georgia at Augusta University AUGUSTA, Ga. (March 19 , 2018) - A small, daily dose of Viagra significantly reduces colorectal cancer risk in an animal model that is genetically predetermined to have the third leading cause of cancer death, scientists report. Viagra cut in half the formation of polyps, an abnormal and often asymptomatic clump of cells on the lining of the intestines that may become cancer, says Dr. Browning, cancer researcher at the Georgia Cancer Center and Department of Biochemistry and Molecular Biology at the Medical College of Georgia at Augusta University. Next steps should include a clinical trial for the drug in patients considered at high risk of colorectal cancer, such as those with a strong family history, multiple previous polyps and chronic intestinal inflammation like colitis, Browning says. Viagra has been used safely for years in a wide range of doses and age groups, from premature infants with pulmonary hypertension to the elderly with erectile dysfunction, he notes. When placed in the drinking water, Browning's team found that Viagra reduced polyps in a mouse model with a genetic mutation that occurs in humans, causing them to produce hundreds of polyps starting as teenagers and essentially always resulting in colorectal cancer, says Browning, corresponding author of the study in the journal . The "little blue pill" could one day have a surprising use: as a cancer prevention drug. Early research in mice suggests that small doses of sildenafil, the ingredient in Viagra responsible for the pill's effects, may prevent colorectal cancer. When the researchers gave the drug to mice that were prone to developing colorectal cancer, the drug was linked to a 50 percent reduction in the number of precancerous polyps that formed in the animals' intestines, compared with mice that weren't given the drug. Still, much more work is needed before researchers will know if Viagra has the same effect in people, the study researchers said. [Viagra Goes Generic: 5 Interesting Facts About the ' Little Blue Pill'] Next steps include testing Viagra in a clinical trial of patients who have a high risk of colorectal cancer, such as people with a family history of the disease, study co-author Darren Browning, a cancer researcher at Augusta University Georgia Cancer Center, said in a statementearlier this month. The mice used in the study had a mutation in a gene called "adenomatous polyposis coli" or APC. This mutation is also found in humans and results in the formation of hundreds of polyps starting in the teenage years, and these growths lead to colorectal cancer, Browning said.

    Viagra and cancer

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