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Tamoxifen liver

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  1. aesmscash Guest

    Tamoxifen liver


    I was prescribed tamoxifen when my breast cancer was diagnosed and have been taking it without obvious problems. My GP did a routine glucose and fasting lipids test (both excellent) together with liver function tests, which came back as some raised enzymes in liver, though I'm not sure what it means! He said that he thought it was the tamoxifen – as I'm virtually teetotal so he couldn't blame alcohol – and will repeat the blood test in four weeks. Could you tell me if this is a common side effect of the drug and if I'm likely to be asked to stop taking it? I used to smoke but when I had a retinal vein thrombosis I stopped. Am I likely to be more at risk of further thrombotic conditions because of this history? Will I ever have children after treatment for Hodgkin's disease? I shall be better able to make an informed choice if I have more facts at my disposal though at the moment I would prefer to remain on the Tamoxifen for the next couple of years if I'm not severely at risk. fluconazole dose for candida The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Hormone therapy using tamoxifen may fight liver cancer by blocking the absorption of estrogen. Listing a study does not mean it has been evaluated by the U. It is not yet known whether receiving tamoxifen is more effective than no further therapy in treating patients with primary liver cancer. RATIONALE: Estrogen can stimulate the growth of cancer cells. PURPOSE: Randomized phase III trial to compare high-dose tamoxifen with no further treatment in treating patients with liver cancer that cannot be surgically removed. Assess the therapeutic role of tamoxifen in patients with inoperable hepatocellular carcinoma in terms of overall survival and quality of life. OUTLINE: This is a randomized, double blind, placebo controlled study of tamoxifen. Patients are randomized to one of 3 treatment arms. Arm I: Patients receive placebo orally twice daily for one year.

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    Hormone therapy using tamoxifen may fight liver cancer by blocking the absorption of estrogen. It is not yet known whether receiving tamoxifen is more effective. is sertraline a benzo Tamoxifen increased hepatic triacylglycerol levels by 72%. liver. Inhibition of fatty acid synthesis might, therefore, ameliorate steatosis/steatohepatitis in breast. The criteria used for diagnosing fatty liver was the ratio of CT value liver/spleen less than 09. The onset of fatty liver was observed at 1–44 months mean 18 months after the start of tamoxifen intake. The area of fatty changes of liver usually progressed from focal to diffuse.

    In 2006, the large STAR clinical study concluded that raloxifene is equally effective in reducing the incidence of breast cancer, but after an average 4-year follow-up, although the difference was not statistically significant, there were 36% fewer uterine cancers and 29% fewer blood clots in women taking raloxifene than in women taking tamoxifen. Tamoxifen improves fertility in males with infertility by disinhibiting the hypothalamic–pituitary–gonadal axis (HPG axis) via ER antagonism and thereby increasing the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and increasing testicular testosterone production. It is taken as a preventative measure in small doses, or used at the onset of any symptoms such as nipple soreness or sensitivity. Other drugs are taken for similar purposes such as clomifene and the anti-aromatase drugs which are used in order to try to avoid the hormone-related adverse effects. Occasionally tamoxifen is used in treatment of the rare conditions of retroperitoneal fibrosis A report in September 2009 from Health and Human Services' Agency for Healthcare Research and Quality suggests that tamoxifen, raloxifene, and tibolone used to treat breast cancer significantly reduce invasive breast cancer in midlife and older women, but also increase the risk of adverse side effects. Some cases of lower-limb lymphedema have been associated with the use of tamoxifen, due to the blood clots and deep vein thrombosis (DVT) that can be caused by this medication. Resolution of the blood clots or DVT is needed before lymphedema treatment can be initiated. Tamoxifen, a non-steroidal anti-estrogen, has been used successfully for a decade as post-operative adjuvant therapy for breast cancer. Tamoxifen is generally well tolerated with few side effects, especially at the typical dose of 10 mg twice daily. However, hepatic effects have been reported after tamoxifen administration and are usually found to be cholestatic in nature. Although previous reports concentrate on tamoxifen as a probable cause of drug-induced hepatotoxicity, very little attention has been focused on the use of tamoxifen in patients with pre-existing liver dysfunction and the possible need for dose adjustment. We present the case of a 48-year-old woman with an acute exacerbation of her pre-existing liver dysfunction and subsequent elevations of tamoxifen blood levels after approximately one year of tamoxifen therapy for adjuvant treatment of breast cancer. Tamoxifen dosing was adjusted based on serum levels.

    Tamoxifen liver

    Tamoxifen-induced fatty liver disease in a Caucasian patient, Tamoxifen induces triacylglycerol accumulation in the mouse liver by.

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  4. Tamoxifen is associated with blood clots leading to deep vein thrombosis and pulmonary embolism. Tamoxifen can cause abnormalities of liver tests, reduced white blood cells, red blood cells, and platelets. Reduced platelets can lead to bleeding.

    • Tamoxifen, Nolvadex Side Effects Weight Gain, Dosage & Dangers
    • Tamoxifen-induced fatty liver in patients with breast cancer.
    • Tamoxifen and liver problems/blood pressure - Breast Cancer Care.

    Mar 7, 1998. reported severe lipaemia induced by tamoxifen, but, to our knowledge, there has been no report of fatty liver as a result of exposure to. viagra after prostate removal Topic Tamoxifen and fatty liver disease Topic Tamoxifen and fatty liver disease Forum Breast Cancer with Another Diagnosis or Comorbidity — Meet others who have breast cancer but also have another health diagnosis/comorbidity such as diabetes, MS, bipolar disorder, HIV or AIDS, Parkinson's Disorder, schizophrenia, etc. Introduction. Tamoxifen is a nonsteroidal antiestrogen that is widely used in the treatment and prevention of breast cancer. Long term tamoxifen therapy has been associated with development of fatty liver, steatohepatitis, cirrhosis, and rare instances of clinically apparent acute liver injury.

     
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