Treatment of discoid lupus erythematosus with chloroquine

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  1. cod3sun Well-Known Member

    Treatment of discoid lupus erythematosus with chloroquine


    Although survival rates have improved, over one half of patients with systemic lupus erythematosus have permanent damage in one or more organ systems. Arthritis and cutaneous manifestations are most common, but renal, hematologic and neurologic manifestations contribute largely to morbidity and mortality.

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    Aug 21, 2018 Hydroxychloroquine is the first-line systemic agent for discoid lupus erythematosus DLE, whereas chloroquine is considered second-line antimalarial therapy in the United States. THIS study was undertaken as a clinical evaluation of the treatment of lupus erythematosus with a tablet composed of quinacrine, 25 mg. hydroxychloroquine, 50 mg. and chloroquine, 65 mg.ΒΆ Certain antimalarial drugs have been shown to be more effective than any therapy previously available in treatment of chronic discoid lupus erythematosus. Quinacrine can be added to hydroxychloroquine for greater efficacy in hydroxychloroquine-refractory patients, and chloroquine can be used in place of hydroxychloroquine in patients who are unable to tolerate hydroxychloroquine. Second-line therapies include oral retinoids, immunosuppressives, immunomodulators, biologics, and pulsed dye laser.

    Systemic lupus erythematosus has fascinated physicians for almost a century and remains the prototypic autoimmune disease. Treatment approaches emphasize using a combination of drugs to minimize chronic exposure to corticosteroids.

    Treatment of discoid lupus erythematosus with chloroquine

    Treatment of Systemic Lupus Erythematosus An Update., Lupus Erythematosus Treated with a Combination of.

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  4. Treatment of discoid lupus erythematosus Begin treatment with the elimination of foci of chronic infection in the body, the normalization of endocrine disorders. Eliminate other irritating and provoking factors, such as direct sunlight, radiation therapy, cold, drafts, external skin damage.

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    • Cutaneous Lupus Erythematosus Current Treatment Options..
    • Treatment of Cutaneous Lupus Erythematosus.

    Systematic administration of chloroquine in discoid lupus erythematosus reduces skin lesions via inhibition of angiogenesis. Hydroxychloroquine and chloroquine with or without quinacrine are currently utilized in the treatment of discoid lupus erythematosus. Hydroxychloroquine is preferred over chloroquine due to the lower risk of side effects, specifically retinal toxicity. Thalidomide, a potent teratogen, has been used in the treatment of discoid lupus erythematosus. Discoid lupus erythematosus DLE is a form of lupus that mainly affects your skin. DLE is different from systemic lupus erythematosus SLE, the most common form of lupus, which can affect any part of the body.

     
  5. GGC Manager Moderator

    Researchers say a drug commonly used to treat malaria and rheumatoid arthritis has also proved effective in treating some aggressive cancers. Quitting HRT - Risks of Stopping Hormone Replacement Therapy Anastrozole User Reviews for Breast Cancer at Researches Say Hydroxychloroquine Can Help Treat Cancer.
     
  6. CHEM_Eugene New Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine An Effective Treatment for Coronavirus. On the Mechanism of Chloroquine Resistance in Plasmodium. PDF Remdesivir and chloroquine effectively inhibit the.
     
  7. tanya_1 XenForo Moderator

    Chloroquine - FDA prescribing information, side effects and uses Chloroquine phosphate tablets should not be used in these conditions unless the benefit to the patient outweighs the potential risks. Usage in Pregnancy Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus.

    Chloroquine and Hydroxychloroquine Side Effects of.