Although survival rates have improved, over one half of patients with systemic lupus erythematosus have permanent damage in one or more organ systems. Arthritis and cutaneous manifestations are most common, but renal, hematologic and neurologic manifestations contribute largely to morbidity and mortality. Indications of chloroquine Plaquenil efectos secundarios Plaquenil ands ex drive Primary care prescribe plaquenil Aug 21, 2018 Hydroxychloroquine is the first-line systemic agent for discoid lupus erythematosus DLE, whereas chloroquine is considered second-line antimalarial therapy in the United States. THIS study was undertaken as a clinical evaluation of the treatment of lupus erythematosus with a tablet composed of quinacrine, 25 mg. hydroxychloroquine, 50 mg. and chloroquine, 65 mg.¶ Certain antimalarial drugs have been shown to be more effective than any therapy previously available in treatment of chronic discoid lupus erythematosus. Quinacrine can be added to hydroxychloroquine for greater efficacy in hydroxychloroquine-refractory patients, and chloroquine can be used in place of hydroxychloroquine in patients who are unable to tolerate hydroxychloroquine. Second-line therapies include oral retinoids, immunosuppressives, immunomodulators, biologics, and pulsed dye laser. Systemic lupus erythematosus has fascinated physicians for almost a century and remains the prototypic autoimmune disease. Treatment approaches emphasize using a combination of drugs to minimize chronic exposure to corticosteroids. Treatment of discoid lupus erythematosus with chloroquine Treatment of Systemic Lupus Erythematosus An Update., Lupus Erythematosus Treated with a Combination of. Can i take ibuprofen and plaquenilPlaquenil and thrombocytopenia Treatment of discoid lupus erythematosus Begin treatment with the elimination of foci of chronic infection in the body, the normalization of endocrine disorders. Eliminate other irritating and provoking factors, such as direct sunlight, radiation therapy, cold, drafts, external skin damage. Discoid lupus erythematosus Symptoms and treatment of.. Cutaneous Lupus Erythematosus Current Treatment Options.. Treatment of Cutaneous Lupus Erythematosus. Systematic administration of chloroquine in discoid lupus erythematosus reduces skin lesions via inhibition of angiogenesis. Hydroxychloroquine and chloroquine with or without quinacrine are currently utilized in the treatment of discoid lupus erythematosus. Hydroxychloroquine is preferred over chloroquine due to the lower risk of side effects, specifically retinal toxicity. Thalidomide, a potent teratogen, has been used in the treatment of discoid lupus erythematosus. Discoid lupus erythematosus DLE is a form of lupus that mainly affects your skin. DLE is different from systemic lupus erythematosus SLE, the most common form of lupus, which can affect any part of the body.