It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Hydroxychloroquine overdose Effects of stopping plaquenil Alcohol and hydroxychloroquine Learn about the medication hydroxychloroquine for Lupus Treatment at Brigham and Women's Hospital. Plaquenil changes the way your immune system works. headache, dizziness, skin rash or black spots when you look at things. Most side effects will go away when your body gets used to the medicine. Tell your doctor if you have these side. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Acne After the pimple dries out, it could leave a dark brown spot in its place. In some cases, the hyperpigmented spot could also be purple or red in colour. This is called postinflammatory. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil and dark spots Plaquenil and skin discoloration, Plaquenil Oral Uses, Side Effects, Interactions. Chloroquine diphosphate salt autophagyChloroquine take how long to workHydroxychloroquine success storiesChloroquine for cancerFluoroquinolones hydroxychloroquine Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. Skin Discoloration and Plaquenil - Arthritis Information. Health conditions that can cause hyperpigmentation.. How to Get Rid of Dark Spots on the Face. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Plaquenil can cause pigment discolouration in the skin. I have two darker patches on the sides of my face which developed quite some time after taking it. It sort of looks like parts of my face are in the shade It might be the cause of your brown spots as well? I also notice that the skin affected feels rougher as well.