Drug name: Glucophage XR, Cetapin XR Generic name: Metformin, Exermet Use: Type 2 diabetes Glucophage XR is an oral diabetes medication which contains the active ingredient metformin. Metformin is used to help control blood sugar levels in people with type 2 (non-insulin dependent) diabetes. It works firstly by reducing the amount of sugar produced by the liver. It also increases the sensitivity of muscle cells to insulin, which helps cells to remove sugar from the blood. It also has the action of delaying absorption of sugar from the intestines after a meal. Metformin thus reduces blood sugar levels both between and straight after eating. The possible Glucophage XR side effects include: • Headache, muscle pain; • Mild nausea, vomiting, diarrhea, gas, stomach pain; • Weakness, feeling faint. More serious side effects may include: • Feeling short of breath; • Fever, chills, body aches and other flu symptoms; • Symptoms of lactic acidosis; • Swelling or rapid weight gain. If you examine your claims data, you’ll likely discover that among your “Top 50 Most Expensive Drugs” is a line item for generic “metformin HCL ER”. Metformin HCL is a longstanding, very inexpensive diabetes treatment. There metformin HCL ER treatments that are very inexpensive. So the question is: Why would this line item be among your “Top 50” most expensive drugs? The answer: There are certain generic forms of metformin HCL ER that are absurdly expensive, while others bear the low-costs that you’d expect. But it’s reasonably likely that many (if not most) of your beneficiaries are unknowingly using the high-cost forms of this drug. To help you understand what is taking place, we provide you with the following Chart, reflecting, first, the “immediate release” version of metformin, and then the 3 “extended release” generic versions of this drug. 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