According to legend it was first brought to Europe by a Countess who had been treated with it in Peru in the 1600s. In 1820, two French chemists isolated quinine from the cinchona bark and quinine became a treatment of reference for intermittent fever throughout the world. Quinine remains an important and effective treatment for malaria today, despite sporadic observations of quinine resistance. Aralen canada Fundus autofluorescence hydroxychloroquine Drug-resistant malaria is spreading, but experts clash over its global risk. By Leslie Roberts Oct. 11, 2017, PM. In what scientists call a “sinister development,” a malaria parasite. Traditionally, chloroquine has been the first line drug of choice for uncomplicated, non-resistant malaria. However, several types of malaria, and most notably Plasmodium falciparum, the most severe and deadly kind, has become resistant to chloroquine in many places. Chloroquine is the drug of choice for the prophylaxis and treatment of sensitive malaria species during pregnancy. Chloroquine should only be given during pregnancy when need has been clearly established. See references. Chloroquine Breastfeeding Warnings. Chloroquine is excreted into human milk. These compounds belonged to a new class of antimalarials, the four-amino quinolines. Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin (chloroquine) and Sontochin (3-methyl-chloroquine). Chloroquine resistant malaria drug of choice CDC - Malaria - Travelers - Malaria Information and., Drugs for Malaria – Fda plaquenilChloroquine phosphate malaria prophylaxis CDC has no limits on the use of chloroquine for the prevention of malaria. Medicines for the Prevention of Malaria While Traveling - Chloroquine.. Chloroquine Use During Pregnancy. Epidemiology, Drug Resistance, and Pathophysiology of.. Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided. Chloroquine has been the drug of choice for protecting against malaria. But because of resistance, it is now only suggested for use in areas where Plasmodium vivax, P oval, and P malariae are present. Chloroquine is the drug of choice in the few malaria-endemic areas free of CRPf. Combining chloroquine and proguanil is an option for CRPf when other first-line antimalarials are contraindicated. Combining chloroquine and proguanil is an option for CRPf when other first-line antimalarials are contraindicated.