Chloroquine intercalation

Discussion in 'Reliable Pharmacy' started by thailandman, 18-Mar-2020.

  1. LLyy Well-Known Member

    Chloroquine intercalation


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    Abstract The first proposed hypothesis about the mechanism of chloroquine CQ action on malaria parasites is DNA intercalation hypothesis which indicates that the site of CQ action is within the nucleus. Later on the interest of research was shifted from nucleus to lysosome due to the report of CQ accumulation within lysosome. Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. A potential new mechanism for the therapeutic effect of chloroquine against intracellular pathogens. In chemistry, intercalation is the reversible inclusion or insertion of a molecule or ion into materials with layered structures. Examples are found in graphite and transition metal dichalcogenides. Model of intercalation of potassium into graphite Examples Graphite. One famous intercalation host is graphite, which.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine intercalation

    Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs, Chloroquine & Hydroxychloroquine supporting chemo.

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  5. Chloroquine. Chloroquine is the prototype anti malarial drug, most widely used to treat all types of malarial infections. It is also the cheapest, time tested and safe anti malarial agent. Mechanism of action The mechanism of action of chloroquine is unclear. Being alkaline, the drug reaches high concentration within the food vacuoles of the.

    • Antimalarial Drugs – Malaria Site.
    • Intercalation chemistry - Wikipedia.
    • Positive Supercoiling of Mitotic DNA Drives Decatenation..

    Effects of chloroquine on the torsional dynamics and rigidities of linear and supercoiled DNAs at low ionic strength. Biopolymers 1989, 28 10, 1695-1703. DOI 10.1002/bip.360281005. J. Michael Schurr, Bryant S. Fujimoto, Pengguang Wu, Lu Song. Prodigiosin Binding to DNA by Intercalation. We studied the effect of chloroquine, an intercalating agent that unwinds the DNA, in relaxed DNA incubated with prodigiosin. For this purpose, we used agarose gel containing chloroquine. We have shown that, at given small concentrations, intercalation of chloroquine strongly facilitates the comet tail formation. At the same time, some part of DNA about 8 % in the nucleoids exits very fast independently on chloroquine, while the largest part of DNA about three quarters does not exit at all.

     
  6. schleicher XenForo Moderator

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Treating Incomplete Lupus and APS with Plaquenill PLAQUENIL® Hydroxychloroquine for the First Thrombosis Prevention in.
     
  7. Menvil User

    Plaquenil Hydroxychloroquine - Side Effects, Dosage. In rare cases, Plaquenil can cause cardiomyopathy, a chronic disease of the heart muscle. If you're taking Plaquenil for an autoimmune condition, your symptoms should begin to improve after a few.

    Hydroxychloroquine Plaquenil