What is the half life of chloroquine

Discussion in 'Plaquenil' started by moneyman23, 13-Mar-2020.

  1. freesignal New Member

    What is the half life of chloroquine


    In addition, the impact of the patient’s physiopathological status and ethnic origin on chloroquine pharmacokinetics is discussed. In humans, chloroquine concentrations decline multiexponentially. The drug is extensively distributed, with a volume of distribution of 200 to 800 L/kg when calculated from plasma concentrations and 200 L/kg when estimated from whole blood data (concentrations being 5 to 10 times higher).

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    For chloroquine, the estimates of absorption rate constant, the total apparent volume of distribution, and elimination half-life of chloroquine are in agreement with previously reported values. The apparent elimination clearance is lower compared to previous studies. This is probably due to the use of different sample matrixes 26–41. An analog of chloroquine – hydroxychloroquine – has a long half-life 32–56 days in blood and a large volume of distribution 580–815 L/kg. The therapeutic, toxic and lethal ranges are usually considered to be 0.03 to 15 mg/l, 3.0 to 26 mg/l and 20 to 104 mg/l, respectively. Hydroxychloroquine has similar pharmacokinetics to chloroquine, with rapid gastrointestinal absorption and elimination by the kidneys. Cytochrome P450 enzymes CYP2D6, 2C8, 3A4 and 3A5 metabolize hydroxychloroquine to N-desethylhydroxychloroquine. Pharmacodynamics. Antimalarials are lipophilic weak bases and easily pass plasma membranes.

    Following administration chloroquine is rapidly dealkylated via cytochrome P450 enzymes (CYP) into the pharmacologically active desethylchloroquine and bisdesethylchloroquine. Chloroquine is 60% bound to plasma proteins and equally cleared by the kidney and liver.

    What is the half life of chloroquine

    Chloroquine and Hydroxychloroquine • LITFL - Life in the Fast Lane, Chloroquine - Wikipedia

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  7. Chloroquine is a weak base and is slowly concentrated within cells by partitioning resulting in intracellular concentrations 60 fold higher than blood concentrations. The peripheral compartment has a Vd of about 200 L/kg and the terminal elimination half-life is 30-60 days. The drug crosses the placenta and is associated with foetal abnormalities.

    • Chloroquine - wikitox.
    • Hydroxychloroquine - Wikipedia.
    • What is chloroquine made out of? AnswersDrive.

    The plasma half-life of chloroquine in healthy individuals is generally reported to be 72-120 hr. In one study, serum concentrations of chloroquine appeared to decline in a biphasic manner and the serum half-life of the terminal phase increased with higher dosage of the drug. For treatment of acute attacks of malaria in adults, one dose is usually taken right away, followed by half the dose 6 to 8 hours later and then half the dose once a day for the next 2 days. For prevention and treatment of malaria in infants and children, the amount of chloroquine phosphate is based on the child's weight. Half-life T ½ In healthy individuals, the plasma half-life of chloroquine is 72 to 120 hours. One study indicated that chloroquine declines in a biphasic manner, with the terminal phase half-life increasing with increasing doses, as follows 3.1 hours after a single 250-mg oral dose, 42.9 hours after a single 500-mg oral dose, and 312 hours after a single 1-g oral dose. 10

     
  8. ravist Guest

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  9. iobo New Member

    Plaquenil Hydroxychloroquine - Side Effects, Dosage. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others.

    Who Is at Risk for Vision Loss with Plaquenil? - American Academy of.
     
  10. uppi User

    Chloroquine plaquil combinations - Ovarian cancer - Inspire The antimalarial drugs chloroquine CQ and hydroxychloroquine HCQ have potential applications in cancer treatment. The growth of MCF-7 and MDA-MB-231 human breast cancer cells in vitro was inhibited by CQ and HCQ and these cells were more sensitive than nontumorigenic MCF-10A breast epithelial cells.

    Hydroxychloroquine Uses, Dosage & Side Effects -