Chloroquine method of action lysosome

Discussion in 'Pharmacy Northwest Canada' started by innersdex, 09-Mar-2020.

  1. goodving XenForo Moderator

    Chloroquine method of action lysosome


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    Plaquenil myasthenia gravis Is hydroxychloroquine Plaquenil and eye floaters

    Mar 08, 2011 Chloroquine-treated ARPE-19 cells demonstrate a marked increase in vacuolation and dense intracellular debris. These are identified as chloroquine-dilated lysosomes and lipid bodies with LAMP-2 and LipidTOX co-localization, respectively. Dilation is an indicator of lysosomal dysfunction. Although the precise mechanism underlying the antimalarial effects of chloroquine remains unknown, chloroquine seems to exert its effects through the weak-base lysosome-tropic feature. When chloroquine enters the lysosome, it becomes protonated because of the low pH within the lysosome, and accumulation of the protonated form of chloroquine within the lysosome leads to less acidic conditions and, thereby, decreased lysosomal function. The high toxicity of concanamycin A and other macrolides precludes their use in clinical therapy. The mode of action of chloroquine is as a weak lipophilic base where the free base passes easily through membranes. It accumulates in the acidic lysosome as it becomes protonated, increasing the pH of the lysosome 35,36. Following exposure to.

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    Chloroquine method of action lysosome

    Chloroquine-Mediated Radiosensitization is due to the., Chloroquine in Cancer Therapy A Double-Edged Sword of.

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  7. Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Whether the protein mediates extrusion of the drug acting as a channel or as a carrier and which is the protonation state of its chloroquine substrate is the subject of a.

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    Chloroquine is an established antimalarial agent that has been recently tested in clinical trials for its anticancer activity. The favorable effect of chloroquine appears to be due to its ability to sensitize cancerous cells to chemotherapy, radiation therapy, and induce apoptosis. The present study investigated the interaction of zinc ions with chloroquine in a human ovarian cancer cell line. Lysosomes, pH and the Anti-malarial Action of Chloroquine Article PDF Available in Nature 235533250-2 February 1972 with 178 Reads How we measure 'reads' Oct 01, 2018 Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA.

     
  8. Dmitry_N. Guest

    This article focuses upon hydroxychloroquine retinopathy. Chloroquine was originally used as an anti-malarial therapeutic. Rx Side Effects New Plaquenil Guidelines and More. Plaquenil Oral Uses, Side Effects, Interactions. Plaquenil
     
  9. savit New Member

    Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health CDC Chloroquine phosphate or hydroxychloroquine sulfate Plaquenil can be used for prevention of malaria only in destinations where chloroquine resistance is not present see Chapter 2, Yellow Fever Vaccine & Malaria Prophylaxis Information, by Country. Prophylaxis should begin 1–2 weeks before travel to malarious areas.

    Medicines for the Prevention of Malaria While Traveling.
     
  10. pileat Well-Known Member

    CDC recommends Coartem for pregnant women with malaria Apr 13, 2018 “In the United States, treatment options for uncomplicated, chloroquine-resistant Plasmodium falciparum and P. vivax malaria in pregnant women are limited to mefloquine or quinine plus.

    Guidelines for Treatment of Malaria in the United States.