Friends and family help but they really just dont get it! Anyways- been diagnosed and have been taking plaquenil since around October- it was helping but my wrists and fingers were still in so much pain that I couldn't even get dressed in the mornings! So I was taking dose packs to help w the pain and my rheumatology finally put me on prednisone- TERRIBLE. I couldnt sleep at night, had awful night sweats, weight gain...it. Tapering off plaquenil Osteo bi-flex triple strength and plaquenil Anxiety and Plaquenil. Some one says that they are working together to control the flares, but I'm not sure if it's the case. I take prednisone 5mg a day. Hi, I have lupus. I take Plaquenil. It has kept my lupus at bay for three years now. The prednisone suppresses your immune system and causes havoc to your body, so you don't want to take it forever. My friend was on long-term prednisone after an organ transplant not-lupus related and she was blown-up and swollen like a balloon. I have been on prednisone for 15 months and am down to 5 mg. I cannot seem to get below that dose without having a flate. My rheumatologist has started me on Plaquenil and has said this should help me get off the prednisone. He said he would rather see me on Plaquenil instead of prednisone due to less side effects of the Plaquenil. So my doctor wanted to put me on methotrexate and I read sooo many terrible things about it that I begged her to let me try something else first before going to the extreme w the methotrexate. Being a 23 yr old female who is getting married in July- weight gain feels like the worst thing that could happen to you. Can i take plaquenil and prednisone together Prednisone and plaquenil -, Danger in taking Plaquenil and Prednisone if its not Lupus ? Yahoo. What does plaquenil do to the immune systemHydroxychloroquine sulfate side effects rheumatoid arthritisHydroxychloroquine and hashimoto's diseaseWhat is the other name for plaquenil I started on Hydroxychloroquine and prednisone at the end of December. Just saw rheumy yesterday because the prednisone wasn't having any affect on 20 mg/day and my rheumy didn't want to increase the prednisone any higher. So she has put me on methotrexate. She said I can take the dose all at. Hydroxychloroquine & Methotrexate DailyStrength. Plaquenil? I have been on prednisone for 15 months. - PMRGCAuk. Compare Plaquenil vs Prednisone - Comprehensive Analysis.. By Connie Rifenburg June 3, 2015 at pm. Ang, I had hair loss pretty severe when I first started on Prednisone, Plaquenil, and Methotrexate. I guess it may depend on the dosage, and hopefully your hair loss will stop as mine did after a few months. Interaction between Plaquenil and Prednisolone There is no known interaction between Plaquenil and Prednisolone in our records. However, an interaction may still exist. Always consult your doctor before taking these medications together. Do not stop taking the medications without a physician's advice. Brand names for prednisone include Deltasone, Rayos, and Prednisone Intensol. Plaquenil and belong to different drug classes. Plaquenil is an antimalarial medication and prednisone is a glucocorticoid. Side effects of Plaquenil and prednisone that are similar include nausea, vomiting, or headache.