Chloroquine resistance testing

Discussion in 'Online Pharmacies Of Canada' started by 2red, 06-Mar-2020.

  1. len4ikku Guest

    Chloroquine resistance testing

    This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. For prevention of malaria in adults, one dose is usually taken once a week on exactly the same day of the week.

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    Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. A standardized in vivo test protocol for assessing the response of P. falciparum to chloroquine was first developed in 1965 and after many revisions, the latest protocol has been put forth by the WHO in 2003.22 It involves a fairly simple, prospective evaluation of the clinical and parasitological response to treatment for uncomplicated malaria. Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt.

    One dose is taken beginning 2 weeks before traveling to an area where malaria is common, while you are in the area, and then for 8 weeks after you return from the area. Your doctor will tell you how many tablets to take for each dose.

    Chloroquine resistance testing

    ARALEN CHLOROQUINE PHOSPHATE, USP Label, Drug Resistance – Malaria Site

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  5. Chloroquine CQ was the cornerstone of anti-malarial treatment in Africa for almost 50 years, but has been widely withdrawn due to the emergence and spread of resistance. Recent reports have suggested that CQ-susceptibility may return following the cessation of CQ usage.

    • Return of chloroquine sensitivity to Africa? Surveillance of..
    • Chloroquine Resistance in Plasmodium falciparum Malaria..
    • Chloroquine MedlinePlus Drug Information.

    Chloroquine needs to be taken 1-2 weeks before traveling to an area with malaria, compared to some alternatives that can be taken 1-2 days before. chloroquine is only effective against malaria from certain areas of the world. chloroquine may worsen psoriasis, seizures, hearing problems, and liver conditions. All patients on long-term therapy with Chloroquine should be questioned and examined periodically, including testing knee and ankle reflexes, to detect any evidence of muscular weakness. If weakness occurs, discontinue the drug. Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen.

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