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The lesions appeared to be occurring in axons and seemed to represent products of axonal degeneration. Tamoxifen is used for hormone-dependent types of breast cancer. It works by blocking the effect of estrogen in the body and thus stopping the growth of cancer cells that possess the estrogen receptors. Since this medication reduces the effects of estrogen, side effects will resemble menopausal symptoms such as hot flashes, vaginal dryness and insomnia. Since then, I've experienced horrible hot flashes, insomnia, depression (worsened), big weight gain, just to name a few. I was told 6 months after chemo that the steroid they gave me had caused cataracts. two years ago noticed I was having severe problems driving at night due to blurring of vision. I am a police officer with many years left before i can retire and good eyesight is ... This was especially severe with oncoming headlights, and rainy situations. Of course, my biggest fear with stopping is recurrence. 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