Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil for apd Is plaquenil a disease modifying Skin Hyperpigmentation with Hydroxychloroquine Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ. I have have been on plaquenil for over a year. It's really made my RA manageable, however, Plaquenil is an anti-malarial and pretty well known for its possible skin discoloration side effects. As you can guess from the title, I now have a beautiful melasma mustache and melasma across my cheeks and forehead. It's great. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Does plaquenil cause melasma Drug-Induced Pigmentation Clinical Presentation History, Physical., Hydroxychloroquine-Induced Pigmentation in Patients With Systemic Lupus. Medications similar to plaquenilAralen tablets Re want to know good stuff about plaquenil Hi, I've been on Plaquenil 400mg per day for close to 3 years and it does help alot. They helped with my hair, my skin, and my joints. Immune & Autoimmune - Lupus want to know good stuff about plaquenil. Melasma skin discoloration from medication rheumatoid. Is taken birth control pills and Plaquenil a cause for.. I'm 59 and suffered fot yrs. the fatigue is the worst and nothing makes it go away. For the severe joint pain, and I mean severe, I've been on prednisone 10 mg a day and plaquenil, but it's too early to tell if the plaquenil's working since it can take 4 to 6 months. With one dose of the prednisone the joint pain went away. The pill is a VERY common cause of dark spots in women. About 30% of women using oral estrogen report having melasma like facial pigmentation. Treatment of hormone-induced melasma works best after breastfeeding has stopped, a woman is no longer pregnant, or her contraceptives have changed. If you experience stomach upset while taking generic hydroxychloroquine, ask your doctor about trying name-brand Plaquenil instead. While these medications contain the same active ingredient, the preparation of generic hydroxychloroquine can sometimes cause stomach irritation that usually does not occur with the brand name Plaquenil.