Viagra discovered

Discussion in 'Legitimate Online Pharmacies' started by gansbrest, 09-Sep-2019.

  1. Anton.Vorozheev Moderator

    Viagra discovered


    Like most scientists and clinicians in this field, I chose a career developing drugs in the hope of improving people’s lives. I say ‘hope’, because often pharmaceutical research and development is a source of frustration and disappointment. Certainly, we make a continual contribution to scientific and medical knowledge, but our work doesn’t always yield new medicines. Very few of us get to work on compounds that ultimately benefit patients. In two decades of research, I’ve managed to be in the right place at the right time on more than one occasion. But the development program I’ve had the greatest involvement in concerns one of the world’s most famous drugs. Its scientific name is sildenafil citrate, but it’s better known as Viagra. I first came across the project in the late 1980s, when I learned colleagues at Pfizer’s laboratories in Sandwich, a small town on England’s southeast coast, had come up with a hypothesis about selectively blocking an enzyme called PDE5. Launched in the United States 20 years ago, Viagra has sold in the billions and become an unexpected source of revenue for its maker Pfizer, as well as copycats worldwide. From its serendipitous discovery to its many counterfeit versions, here is a look back at how the world embraced the little blue pill that treats impotence. Discovered by chance At the start of the 1990s, teams at Pfizer experiment with a new drug called Sildenafil used to treat heart conditions. It proves powerless in calming thoracic pain brought on by such infections, but the drug has an unexpected side-effect on men: it causes an erection. The majority of the male volunteers in the experiments also report a significantly improved sex life. Pfizer changes tack, focusing instead on researching male impotence, a problem that affects a third of men over 40. Up to this point the treatment for erectile disfunction has been poor: Only impractical and inefficient options exist, such as mini-suppositories inserted into the urethra or injections in the penis.

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    Aug 3, 2018. One of mankinds most dearly loved drug Viagra was an accidental discovery and one that became lifechanging for a lot of men and women. Dec 12, 2017. Many of the medical inventions we know today were discovered by accident. Take penicillin for example. Sir Alexander Fleming accidentally. Sildenafil Viagra is a extremely selective inhibitor of cGMP-specific phosphodiesterase sort 5 PDE5 and has been extensively used for the treatment of erectile dysfunction 1.

    UK-92,480 was first synthesised in the Sandwich laboratories of Pfizer Ltd, UK in 1989, and resulted from a discovery programme aimed at developing a selective inhibitor of PDE5. The origins of the project that eventually led to the discovery and development of Viagra date from around the mid 1980s. At this time, scientists working at the Pfizer European Research Centre were interested in potential new approaches to the treatment of several cardiovascular diseases. Initially the famous blue pill was developed as a treatment for angina - unfortunately the trials were disappointing and the drug did little to help prevent angina. However, the researchers did notice a surprising side effect – an increased number of erections! “What was amazing about this study was that we saw a restoration of the erectile response. Now we were on to something which could only be described as special,” Chris Wayman, a senior scientist at Pfizer explained, as reported by the BBC. “In many ways you learn as much about your medicine after it’s launched as you knew before,” said Patrick Vallance, head of drug discovery at GSK. Before Viagra was launched in 1998, there was no oral medication for erectile dysfunction. But today Viagra is one of the most prescribed drugs in the world for erectile dysfunction.2.

    Viagra discovered

    BBC News - Viagra and other drugs discovered by accident, You won't believe what Viagra was used for before ED Health24

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  4. Jul 23, 2018. Excited to think what he may have discovered, Fahlberg left his dinner and hurried back to the laboratory, where he had been examining the.

    • From Velcro to Viagra 10 products that were invented. - History Extra.
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    How Was Viagra Discovered? Viagra Discovery & History. The power of the Viagra discovery and how it continues to be one of the most purchased drugs in the world. Viagra Online from $0.59. Are any interesting facts about Viagra discovery and history? Let’s get all the details! From Viagra to Valium, the drugs that were discovered by accident From Alexander Fleming onwards, the lives of millions have been transformed and saved by treatments that scientists were not even. Apr 27, 2015. "I was as surprised as anyone when my research on a potential treatment for heart disease revealed a side effect that sparked a sexual health.

     
  5. greenkaktus XenForo Moderator

    Generic Cialis is used to treat erection problems in men. It is the only drug which is not only fast acting (works in 30 minutes) but is also know to be effective for as long as 36 hours, thus enabling you to choose the moment that is just right for you as well as your partner. Millions of men have benefited from Cialis as it works effectively in mild, moderate or severe Erectile Dysfunction. NJ is the first state to set formal standards requiring testing of public drinking water systems for perfluorooctoanic acid (PFOA) and perfluorononanoic acid (PFNA). More When you lay a baby down to sleep, be sure sleep time is a safe time! They should not share their sleep surfaces with adults, pets or other children, even their own twin. Safe Sleep Tips Healthy New Jersey 2020 is the state’s health improvement plan for the decade. It is modeled after the federal Healthy People 2020 initiative and is the result of a multiyear process that reflects input from a diverse group of individuals and organizations. Safe Online Viagra Orders New Treatment Options For Ed - Doug Fine Buy Cheap Viagra Online
  6. Delini Guest

    Propranolol - from devestating anxiety to calm in 1 day. Propranolol helps with. day twice a day very low dosage in march and april. i am trying to wean myself off them now to one a day but latley now i have feel more.

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  8. Delini XenForo Moderator

    How Viagra was discovered by Pfizer — Quartz Sildenafil, the active ingredient in Viagra, was originally developed to treat cardiovascular problems. Viagra was approved by the US Food and Drug Administration for use as an erectile dysfunction drug.

    How Viagra Was Invented - ThoughtCo