Chloroquine treatment lysosome

Discussion in 'International Pharmacy' started by linad, 13-Mar-2020.

  1. devochka User

    Chloroquine treatment lysosome


    Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

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    Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Lys05 produced more potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models compared with HCQ. Oct 01, 2018 Treatment of uncomplicated malaria due to Chloroquine-sensitive Plasmodium species Adults An initial dose of 1 g salt = 600 mg base followed by an additional 500 mg = 300 mg base after six to eight hours and a single dose of 500 mg = 300 mg base on each of two consecutive days. Upon chloroquine treatment lysosome pH of murine peritoneal macrophages is augmented as unprotonated CQ accumulates inside lysosomes. However, due to the action of ATPase proton pumps, the drug becomes protonated and unable to leave this vesicle.

    Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria.

    Chloroquine treatment lysosome

    Could an old malaria drug help fight the new coronavirus?, Chloroquine - FDA prescribing information, side effects and uses

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  3. Treatment of normal human fibroblasts with U18666A, an amphiphilic drug that inhibits cholesterol transport and causes accumulation of cholesterol in lysosomes, rescued cells from lysosome-dependent cell death induced by the lysosomotropic detergent O-methyl-serine dodecylamide hydrochloride MSDH, staurosporine STS, or cisplatin.

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    Sep 15, 2013 Originally synthesized as a treatment for malaria, chloroquine or the closely related compound, hydroxychloroquine, is now widely used for the treatment of rheumatoid arthritis, lupus erythematosus and sarcoidosis and a number of dermatological conditions 16–20. Nov 25, 2019 Chloroquine is used to treat and to prevent malaria. Chloroquine is also used to treat amebiasis infection caused by amoebae. Chloroquine may also be used for purposes not listed in this medication guide. Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion.

     
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