Chloroquine cancer therapy

Discussion in 'International Pharmacy' started by KVG, 26-Feb-2020.

  1. kletka Guest

    Chloroquine cancer therapy


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

    What is the mechanism of action of chloroquine and primaquine What does hydroxychloroquine do for ra

    AbstractBackgroundThe anti-malarial drug chloroquine has recently been discovered as a novel anti-tumor agent. This article is to review the recent development of chloroquine being used in cancer therapy. MethodsPubMed, ScienceDirect and ClinicalKey served as the major databases. Key words included ‘chloroquine’, ‘cancer’, and ‘autophagy’. This drug may add to the chance of getting some types of cancer. Talk with the doctor. Keep away from children. Accidental exposure may cause death. If a child takes this drug by accident, get medical help right away. If your child is pregnant Tell the doctor if your child is pregnant or becomes pregnant. Chloroquine What to know about potential coronavirus treatment TODAY'S MUST-READS Italy coronavirus death toll passes China's for first time How to help Italy Coronavirus patients with diabetes -- like Tom Hanks -- can have more complications. Doctor says he's 3-4 weeks from developing treatment to 'neutralize' coronavirus.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine cancer therapy

    Colorado scientists weigh in on chloroquine as possible., Chloroquine - Memorial Sloan Kettering Cancer Center

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  6. At the Methodist Hospital Cancer Center in Houston, medical oncologist Jenny Chang is leading a phase II trial investigating whether chloroquine improves the effects of chemotherapy in metastatic breast cancer patients for whom treatment with anthracyclines failed. Blood-pressure Medications

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    Treatment of uncomplicated malaria due to susceptible strains of P. falciparum, P. malariae, P. ovale, and P. vivax. Prophylaxis of malaria in geographic areas without resistance to chloroquine. Nov 15, 2015 Summary. Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Note based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. Chloroquine is a promising drug for cancer therapy and relatively safe, especially for a short period of time. Unexpected side effects on organs, such as the kidney, however, could occur, especially when combined with anticancer drugs, possibly through the inhibition of autophagy.

     
  7. Develar User

    This article focuses upon hydroxychloroquine retinopathy. Chloroquine was originally used as an anti-malarial therapeutic. Retinal Detachment in a Patient with Hydroxychloroquine. Hydroxychloroquine toxicity - EyeWiki Ocular side effects of anti-rheumatic medications what a.
     
  8. Hydroxychloroquine Side Effects, Dosage, Uses, and More Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more.

    Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.