While the exact percentage of RA patients who experience sleep problems is hard to nail down, more than 80% of people with RA report fatigue as part of their symptoms. Why Sleep Matters Sleep problems can increase levels of stress hormones and aggravate flares, says Rochelle Rosian, MD, a Cleveland Clinic rheumatologist. Clinical pharmacokinetics and metabolism of chloroquine Hydroxychloroquine sulfate bp csr Hydroxychloroquine sulfate tablets usp 200 mg side effects Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. While today it is used to treat autoimmune conditions, such as rheumatoid arthritis and lupus, it was originally used as an anti-malaria drug. Aug 29, 2014 One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. For women, start with 100 pounds, and add 5 pounds for every inch over 5 feet. For men, start with 106 pounds, and add 6 pounds for every inch over 5 feet. The maximum dose of Plaquenil is 6.5 mg/kg of ideal body weight per day, regardless of whether a person is overweight, underweight, or normal weight. “When you sleep, you make all those brain chemicals that you need to feel better. And even if you’re not flaring, you may not manage your pain as well if you’re not sleeping. What percent of people with arthritis benefit from plaquenil Benefits Of Plaquenil - Sjogren's World, The Risk of Retinal Toxicity with Plaquenil Chloroquine phosphate dosage reefHow does azithoprine work with plaquenil fir lupusHydroxychloroquine substitutionsChloroquine vs chloroquinine Up to half of patients treated with the arthritis drug hydroxychloroquine Plaquenil are prescribed more than the recommended maximum amount, according to new research. In separate studies, Canadian and U. S. researchers found that 30 to 50 percent of patients didn’t receive the dose outlined in treatment guidelines; a smaller percentage didn’t get recommended eye exams. Wrong Hydroxychloroquine Dose Is Common, Putting Eyes at Risk.. Protecting your eyesight when taking Plaquenil Lupus.. How Does Plaquenil Work For Rheumatoid Arthritis. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil is often added in lupus patients with arthritis, as it can help lower the dosage of, or possibly eliminate the use of, prednisone in some patients. Some side effects of Plaquenil are diarrhea, skin rash, sun-sensitivity and, rarely, eye problems pigment deposits in the back of the eye. Besides what I have already written to you, the only advice I can give is to consider all the ways this disease impacts your life and weigh that against the possible side effects. Also consider the prognosis of the condition. In the end, no one can say who will be among the small percentage of people who experience side effects.