Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil letter Excessive sleepiness plaquenil The optimal treatment of RA requires a comprehensive program that combines medical, social, and emotional support for the patient. It is essential that the patient and the patient’s family be educated about the nature and course of the disease. Treatment options include medications, reduction of joint stress. Early, aggressive disease management is critical for halting disease progression and joint destruction in patients with rheumatoid arthritis. Combination therapy with at least two disease-modifying antirheumatic drugs, such as methotrexate MTX, sulfasalazine, or hydroxychloroquine, is often more effective than monotherapy in reducing disease activity. The study showed that the combination of methotrexate and hydroxychloroquine is equivalent to leflunomide in improving the disease activity and is similar in the hepatic safety profile. We conclude that methotrexate in combination with hydroxychloroquine is equal in efficacy to new drug leflunomide as an initial therapy in severe active rheumatoid arthritis. Hydroxychloroquine may also be used for purposes not listed in this medication guide. Hydroxychloroquine is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine and leflunomide together Hydroxychloroquine oral and leflunomide oral Drug., Combination Therapy for Rheumatoid Arthritis in the Era of Biologicals Tier for hydroxychloroquineChloroquine cancer therapy Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine Plaquenil. Evaluation of efficacy of combination of methotrexate and.. Anyone on Leflunomide, Hydroxychloroquine and MTX? - NRAS. MONDAY, Nov. 26, 2007 HealthDay News -- Combining an older synthetic drug with a newer, "biologic" medication may work best to ease the joint swelling and tenderness of rheumatoid arthritis, a new study finds. Hydroxychloroquine oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or. The Combination of Leflunomide Arava and Methotrexate is Safe & Efficacious for the Treatment of Rheumatoid Arthritis. Methotrexate MTX, an anti-metabolite that inhibits purine pathways, has been the hallmark of standard of care for many years in the treatment of rheumatoid arthritis RA.