One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Long term chloroquine effects How do you pronounce hydroxychloroquine Lc3 mitotracker chloroquine Sulfasalazine plaquenil Dose and duration. Both the daily and total cumulative dose can increase the risk of Plaquenil toxicity. “To minimize this, the dose should be maintained at less than 5.0 mg/kg per day for real body weight, rather than ideal weight,” said Dr. Mieler. The 400-mg dosage has traditionally been very popular, said Dr. Sarraf. Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except. Dr. Fraunfelder “One of the main rules, but not a hard rule, is if it’s a drug toxicity, it usually is bilateral.” Dr. Fung “I’m always concerned that the prescribing doctors are not completely aware of the dose-related toxicity of chloroquine and hydroxychloroquine. So I always check and calculate the dose. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Whats the dosage that causes plaquenil toxicity Hydroxychloroquine Plaquenil Toxicity and Recommendations., What Conditions does Plaquenil Treat? - WebMD Hydroxychloroquine can suppress appetiteCan hydroxychloroquine be used for thyroidWhat type of drug is plaquenilChloroquine sulfa allergyChloroquine pretreatment degradation toxicity Sep 13, 2019 Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Plaquenil Side Effects Common, Severe, Long Term -. Rx Side Effects New Plaquenil Guidelines and More - American.. Hydroxychloroquine Plaquenil Toxicity and.. Jan 03, 2020 Weight based dosage in adults and pediatric patients 13 mg/kg 10 mg/kg base, not to exceed 800 mg 620 mg base followed by 6.5 mg/kg 5 mg/kg base, not to exceed 400 mg 310 mg base, at 6 hours, 24 hours and 48 hours after the initial dose. PLAQUENIL film-coated tablets cannot be divided, therefore they should not be used to treat patients who weigh less than 31 kg. Hydroxychloroquine increases the QT interval and should not be administered with other drugs known to prolong the QT interval. Ventricular arrhythmias and torsade de pointes have been reported with the use of hydroxychloroquine. Citalopram causes dose-dependent QT interval prolongation. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. For people who weigh less than 80 kg, a lower daily dose is prescribed, up to a maximum of 5 mg/kg of body weight.