In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. How does chloroquine work Chloroquine dose for rheumatoid arthritis Nov 09, 2018 Hydroxychloroquine is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine may also be used for purposes not listed in this medication. Characteristic signs of retinal toxicity related to the use of chloroquine or hydroxychloroquine include paracentral or pericentral scotomas and a bull's eye maculopathy, shown as bilateral pigmentary changes of the macula with relative sparing of the central fovea. The mechanism to explain these clinical signs remains unclear. For women, start with 100 pounds, and add 5 pounds for every inch over 5 feet. For men, start with 106 pounds, and add 6 pounds for every inch over 5 feet. The maximum dose of Plaquenil is 6.5 mg/kg of ideal body weight per day, regardless of whether a person is overweight, underweight, or normal weight. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Retinal changes with the use of hydroxychloroquine LONGITUDINAL CHANGES IN EYES WITH HYDROXYCHLOROQUINE RETINAL., Hydroxychloroquine Retinal Toxicity Early Signs Will plaquenil show up on a drug screenPlaquenil picturesPlaquenil missed dosePlaquenil for lupus mechanismPlaquenil memory loss Oct 12, 2019 Looking for subtle retinal changes. Hydroxychloroquine is commonly used to treat autoimmune inflammatory diseases such as rheumatoid arthritis. A rare side effect is retinal toxicity, which can cause irreversible and progressive vision loss. Novel Image Analysis Platform May Detect Early Signs of.. Protecting your eyesight when taking Plaquenil Lupus.. My Take on New Ocular Screening Guidelines for Plaquenil.. The incidence of retinal toxicity is associated with the cumulative dose of the drug, increasing significantly beyond 1,000 g of HCQ. This cumulative dose is created when the common dose of 400 mg/day is used for 6.8 years. Hydroxychloroquine is metabolized and secreted by both the liver and the kidneys. Hydroxychloroquine is a well tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity. Within the eye, hydroxychloroquine negatively impacts the cornea, ciliary body, and retina. Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy.