Plaquenil retinal toxicity screening

Discussion in 'Chloroquine Phosphate 500 Mg' started by errror, 29-Feb-2020.

  1. Mr.Seven Guest

    Plaquenil retinal toxicity screening


    It succinctly makes the case for screening, and outlines the evidence for screening methods and parameters to know for screening. Because this information is pretty important (2), I wanted to highlight some of the key points made by the publication.

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    In particular, chloroquine and hydroxychloroquine Plaquenil are two such medications, with the potential for retinal toxicity. Given that the retinal damage from these medications is largely irreversible, screening by a retinal specialist is critical to detect early retinal toxicity to try and limit the extent of visual loss. Plaquenil Screening. Plaquenil hydroxychloroquine is a medication used to treat many rheumatologic diseases, including rheumatoid arthritis. Generally it is safe, but one of the side effects of Plaquenil is retinal toxicity. If retinal toxicity is not detected, and Plaquenil is continued, it can cause irreversible vision loss. Plaquenil is known to show retinal toxicity which can effect the vision and it is imperative to be able to spot any changes and to contact the patient's rheumatologist to notify them about the changes. The presentation goes over how to spot and what testing to perform to make sure there is no retinal toxicity.

    Visual fields and SD-OCT are not necessary for baseline measurements unless there is pre-existing retinal pathology that needs to be documented. I’m sure that this may continue to change and evolve the more we learn; but here are my conclusions: A comprehensive ophthalmology exam should be performed within 1 year of starting hydroxychloroquine or chloroquine.

    Plaquenil retinal toxicity screening

    Retinal toxicity associated with chronic exposure to hydroxychloroquine., Plaquenil Screening Mountain States Eye Center

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  4. Risk factors for toxicity. Reported risk factors for toxicity include daily dose 400 mg, or 6.5 mg/kg ideal/lean body weight for short individuals; cumulative dose 1000 g; duration of use 5 years; renal or hepatic dysfunction; obesity; age 60 years; and pre-existing retinal disease or maculopathy 31.

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    • Hydroxychloroquine and Chloroquine Retinopathy..

    The American Academy of Ophthalmology released an updated set of screening recommendations for hydroxychloroquine Plaquenil and chloroquine to account for the many studies that have shown the effects of these medications on the retina 1. It succinctly makes the case for screening, and The incidence of HCQ retinopathy is very low. In fact, HCQ is estimated at having a 0.5% incidence of retinal toxicity after 5 years of therapy.5,6 Retinal toxicity secondary to HCQ is irreversible and can continue to progress following cessation of therapy. Prompt screening and serial monitoring, with the utilization of imaging modalities, is paramount importance to early detection. Remember, any patient who is at a high risk for Plaquenil toxicity should be examined on an annual basis following the baseline exam. The goal of monitoring/screening is to identify early macular damage prior to irreversible vision loss or even before visible signs of bull’s eye maculopathy.

     
  5. peter1 Well-Known Member

    Download PDF Many systemic medications may cause retinal toxicity. Threshold Amsler grid as a screening tool for asymptomatic. Amsler Grid - an overview ScienceDirect Topics Chloroquine and Hydroxychloroquine Toxicity Workup Approach.
     
  6. backdrift Moderator

    Plaquenil hydroxychloroquine sulfate dosing, indications. For individuals with significant risk factors daily dose of hydroxychloroquine sulfate 5.0 mg/kg base of actual body weight, subnormal glomerular filtration, use of tamoxifen citrate or concurrent macular disease monitoring should include annual examinations which include BCVA, VF and SD-OCT; for individuals without significant risk factors.

    Hydroxychloroquine Uses, Dosage & Side Effects -