She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Can plaquenil cause drusen Mefloquine and chloroquine wiki Chloroquine resistance mechanism Fundus Autofluorescence FAF Early hydroxychloroquine toxicity can also be detected on autofluorescence as an increased ring of signal within the parafoveal and extramacular regions, which is indicative of photoreceptor dysfunction and RPE dysfunction. Chloroquine and its derivative, hydroxychloroquine sulfate, which have been useful in treating malaria and in larger doses, collagen-vascular disease, cause a cumulative dose-related pigmentary retinopathy. Fundus - pigmentry changes, vascular attenuation & optic disc pallor Toxicity is more dependent on total daily dose than on cumulative. Fundus autofluorescence images of the left eye of a 59-year-old women with sarcoidosis who received 200 mg of hydroxychloroquine sulfate twice daily for 15 years. Her visual acuity was 20/20 bilaterally with normal red light central 80-point visual fields. A fundus examination demonstrated subtle macular pigmentary change A. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Fundus in chloroquine FUNDUS AUTOFLUORESCENCE FINDINGS IN EARLY CHLOROQUINE., Drug induced maculopathy - EyeWiki How long for chloroquine to work malaria Year for chloroquine should receive baseline examination ideally within six months of starting hydroxychloroquine or chloroquine and definitely within 12 months. C Baseline examination should include a fundus photography and spectral domain optical coherence tomography. GPP Hydroxychloroquine and Chloroquine Retinopathy.. Fundus Autofluorescence in Hydroxychloroquine Toxicity.. FUNDUS AUTOFLUORESCENCE FINDINGS IN EARLY CHLOROQUINE MACULO.. Purpose To determine the sensitivity of spectral domain ocular coherence tomography SD-OCT and fundus auto fluorescence FAF images as a screening test to detect early changes in the retina prior to the onset of chloroquine retinopathy. Method The study was conducted using patients taking chloroquine CQ, referred by the Rheumatology Department to the Ophthalmology Department at. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen.