Duloxetine for depression

Discussion in 'Canadian Rx Pharmacy Online' started by alestar, 27-Aug-2019.

  1. WeaSea Well-Known Member

    Duloxetine for depression


    Bei Duloxetin handelt es sich um einen sogenannten, selektiven Serotonin-Noradrenalin-Wiederaufnahmehemmer, der als Therapeutikum gegen Angststörungen, Polyneuropathie, Depressionen und Inkontinenz eingesetzt wird. In Europa fehlt bislang die Zulassung gegen Fibromyalgie, in den USA ist das Medikament hierfür schon zugelassen. Die interne Kommunikation des Hirns funktioniert über Neuronen und Neurotransmitter. Jede Zelle schüttet bestimmte Transmitter aus, die dann von anderen Zellen und ihren Rezeptoren erkannt werden. Es entsteht ein riesiges, kommunikatives Netzwerk, welches selbst Wissenschaftlern noch nicht vollständig begreiflich ist. Einige dieser Botenstoffe rufen bestimmte Wirkungen hervor, so gilt Serotonin beispielsweise als Glückshormon. Fehlt Serotonin oder ist die Konzentration zu niedrig, können Depressionen entstehen. Duloxetine hydrochloride is a type of antidepressant called a serotonin and noradrenaline reuptake inhibitor (SNRI). It works by enhancing the activity of the neurotransmitters serotonin and noradrenaline in the brain. Neurotransmitters are natural body chemicals that act as chemical messengers between the nerve cells. Serotonin and noradrenaline are neurotransmitters known to be involved in regulating emotions, mood and behaviour, among other things. In depression and anxiety disorders less serotonin and noradrenaline than normal is released from nerve cells in the brain. Duloxetine works by stopping the serotonin and noradrenaline that has been released from being reabsorbed back into the nerve cells in the brain. This helps to prolong their effects and over time this helps to lighten mood and relieve depression.

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    CYMBALTA Traitement du trouble dépressif majeur. Traitement de la douleur neuropathique diabétique périphérique. Traitement du trouble anxiété généralisée. Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, and. Duloxetine is a medicine available in a number of countries worldwide. A list of US medications equivalent to Duloxetine is available on the website.

    Paroxetine, sold under the brand names Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive-compulsive disorder, social anxiety disorder, panic disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder. It has also been used in the treatment of hot flashes and night sweats associated with menopause. The United States Department of Justice fined Glaxo Smith Kline $3 billion in 2012, including a sum for withholding data on paroxetine, unlawfully promoting it for under-18s and preparing an article, following one of its clinical trials, study 329, that misleadingly reported the drug was effective in treating adolescent depression. Paroxetine is primarily used to treat major depressive disorder, obsessive-compulsive disorder, post-traumatic stress disorder, social anxiety disorder, panic disorder, generalized anxiety disorder, premenstrual dysphoric disorder and menopausal hot flashes. A variety of meta analyses have been conducted to evaluate the efficacy of paroxetine in depression. Food and Drug Administration approved low-dose paroxetine for the treatment of moderate-to-severe vasomotor symptoms such as hot flashes and night sweats associated with menopause. They have variously concluded that paroxetine is superior or equivalent to placebo and that it is equivalent or inferior to other antidepressants. Paroxetine shares many of the common adverse effects of SSRIs, including (with the corresponding rates seen in people treated with placebo in parentheses): nausea 26% (9%), diarrhea 12% (8%), constipation 14% (9%), dry mouth 18% (12%), somnolence 23% (9%), insomnia 13% (6%), headache 18% (17%), hypomania 1% (0.3%), blurred vision 4%(1%), loss of appetite 6% (2%), nervousness 5% (3%), paraesthesia 4% (2%), dizziness 13% (6%), asthenia (weakness; 15% (6%)), tremor 8% (2%), sweating 11% (2%), and sexual dysfunction (≥10% incidence). Duloxetine (Cymbalta) is a serotonin and norepinephrine reuptake inhibitor in the same class as venlafaxine (Effexor). In Europe it is marketed for the treatment of stress urinary incontinence; it is not approved for that indication in the United States. In one open-label study1 there were seven suicide attempts among 1,279 patients in one year (one suicide attempt per 115 patient-years of drug exposure) and no cases of fatal acute overdose. Food and Drug Administration (FDA) for use in the treatment of major depressive disorder and of diabetic peripheral neuropathic pain. Duloxetine should not be used in patients taking a monoamine oxidase inhibitor (MAOI), including a period of five days before initiation of the MAOI and 14 days after its discontinuation.2 Duloxetine is metabolized extensively by cytochrome P450 enzymes 1A2 and 2D6. Duloxetine plasma concentrations may be increased significantly by some antidepressants, quinidine, and quinolone antibiotics. Duloxetine may increase the plasma concentrations of other antidepressants, antipsychotics, and type 1C antiarrhythmics such as propafenone (Rythmol) and flecainide (Tambocor). Serum alanine transaminase levels increased to more than three times the upper limit of normal in about 1 percent of patients taking duloxetine in placebo-controlled trials2; alcohol may increase this risk. However, there have been no reports of hepatic failure.

    Duloxetine for depression

    Questions & Answers Advantages of Cymbalta for depression., Duloxetine - Wikipedia

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    In an eight-week study4 of patients with mild to moderate depression, duloxetine, 40 mg daily, produced a response rate of 44 percent. Since depression impacts all body systems, antidepressant treatments should relieve both the emotional and physical symptoms of depression. Duloxetine. Overall, venlafaxine and duloxetine appear to be similar in efficacy and tolerability in treating late life depression. However, venlafaxine has been more.

     
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