Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Can plaquenil make psoriatic arthritis worse Plaquenil 200 mg uso Repeat 10-2 HVF testing demonstrated the dense paracentral scotomas. SD-OCT showed loss of the parafoveal inner/outer segment junction, thinning of the parafoveal outer nuclear layer, and a loss of the normal foveal depression, which is characteristic for hydroxychloroquine retinal toxicity Figure 3. Of course the aim is avoid drug related retinal toxicity, which on ophthalmic examination, appears as the classic Bull’s eye change affecting the macula. Once retinal toxicity from hydroxychloroquine occurs, it is thought that the retinal changes are permanent and the disease can progress even if hydroxychloroquine is stopped for 1 to 3 years. Today it is recommended that every single person on Plaquenil get a visual field 10-2 test, plus one of the three other highly sensitive screening tests the FAF fundus autofluorescence imaging, the SD-OCT spectral domain optical coherence, or the multifocal electroretinogram mfERG,” Thomas says. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil ocular testing Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria, My Take on New Ocular Screening Guidelines for Plaquenil. Plaquenil natural alternative Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Plaquenil Side Effects Common, Severe, Long Term -. Protecting your eyesight when taking Plaquenil Lupus.. How Do Ophthalmologists Look for Plaquenil Damage.. Hydroxychloroquine Plaquenil is a very useful drug to treat Rheumatoid Arthritis and Lupus but it can have some significant visual side effects unless properly dosed and monitored. What can Hydroxychloroquine Plaquenil do to my eyes? Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. RECOMMENDED SCREENING. Baseline screening within 1 year of initiating medication. Annual screening after five years if no risk factors. Biomicroscopy, 10-2 HVF and SD-OCT on annual screening. Ancillary testing optional if no risk factors or other ocular comorbidities on baseline screening however commonly tested.