Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Hydroxychloroquine sulfate tabs 200mg Chloroquine rob holland Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Call your doctor right away if you have any eyesight changes like blurred or foggy eyesight, trouble focusing or reading, or trouble seeing in dim light. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine elimination route On the question of dose-dependent chloroquine elimination., Chloroquine Indications, Side Effects, Warnings - Plaquenil cyst buster Anti-malarial resistance is, and continues to be a significant challenge in the fight against malaria and a threat to achieving malaria elimination. In Zambia, chloroquine CQ, a safe, affordable and well-tolerated drug, was removed from use in 2003 due to high levels of resistance evidenced with treatment failure. En-route to the ‘elimination’ of genotypic chloroquine.. Chloroquine Oral Uses, Side Effects, Interactions.. PDF En-route to the ‘elimination’ of genotypic chloroquine.. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of chloroquine to prevent and treat malaria in children. However, children are more sensitive to the effects of this medicine than adults. Route of Elimination Excretion of chloroquine is quite slow, but is increased by acidification of the urine. Half Life 1-2 months Uses/Sources For the suppressive treatment and for acute attacks of malaria due to P. vivax, P.malariae, P. ovale, and susceptible strains of P. falciparum, Second-line agent in treatment of Rheumatoid Arthritis A308. Chloroquine analogues in drug discovery New directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases. Chloroquine and hydroxychloroquine, two.