Chloroquine effect on lysosomes

Discussion in 'Canadian Pharcharmy' started by MARKATUN, 28-Feb-2020.

  1. Foggy4 Well-Known Member

    Chloroquine effect on lysosomes


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine is a useful antimalarial and anti-inflammatory drug. It affects the lysosomes of malarial parasites 15, those of leukocytes and pancreatic exocrine cells 6, 7, and those of liver cells in the rat 4. In these examples the lysosomes are altered in structure, leading to the formation of myeloid bodies. If a child takes chloroquine by accident, get medical help right away. If you are 65 or older, use chloroquine with care. You could have more side effects. Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using chloroquine while you are pregnant. Preventing malaria In this study, ARPE-19 cells were treated with chloroquine to inhibit lysosomal function. Chloroquine-treated ARPE-19 cells demonstrate a marked increase in vacuolation and dense intracellular debris. These are identified as chloroquine-dilated lysosomes and lipid bodies with LAMP-2 and LipidTOX co-localization, respectively.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine effect on lysosomes

    Effects of chloroquine on viral infections an old drug., Chloroquine Indications, Side Effects, Warnings -

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  6. Chloroquine comes as a tablet, liquid, or injection. Your dose will depend on your medical condition, age, weight, and response to treatment. You can take this medicine with food if it causes an.

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    Hydroxychloroquine and chloroquine are antimalarial drugs commonly used for the treatment of rheumatic diseases. Multiple mechanisms might explain the efficacy and adverse effects of these drugs. Mal content in the lysosomes. In order to get more insight on the effect of CQ on these organelle s, we analyzed the subcellular distribution of LAMP1, a marker protein for late endosomal compartments and lysosomes 26,27, by immunofluorescence microscopy. This analysis was performed under basal growing Chloroquine has been used as an anti-malarial drug and is known as a lysosomotropic amine as well. The effects of chloroquine on lysosomal integrity in cultured rat hepatocytes were studied by.

     
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  8. alexflash Well-Known Member

    A favorable effect of hydroxychloroquine on glucose and. Antimalarials and effects on glucose metabolism. The antidiabetic effect of chloroquine CQ was first described in 1984 in a patient with severe insulin resistance in whom the addition of CQ dramatically reduced his insulin requirements Blazar et al. 1984.

    Chloroquine - Wikipedia