It is the most common titrimetric procedure used in pharmacopoeial assays and serves a double purpose: it is suitable for the titration of very weak acids and very weak bases, and it provides a solvent in which organic compounds are soluble. The most commonly used procedure is the titration of organic bases with perchloric acid in anhydrous acetic acid. Plaquenil overdose amount Chloroquine-medicated salt Plaquenil maculopathy dosage Aralen tablets The types of compounds, in a non-aqueous medium, that may be titrated as acids, usually by lithium methoxide or tetrabutyl ammonium hydroxide, include acid halides, acid anhydrides, carboxylic acids, amino acids, enols such as barbiturates and xanthines, imides, phenols, pyrroles and sulfonamides. The types of compounds, in a non-aqueous ASSAY BY NON-AQUEOUS TITRATIONS • Acidimetry in Non-aqueous Titrations—It can be further sub-divided into two heads, namely i Titration of primary, secondary and tertiary amines, and ii Titration of halogen acid salts of bases. • Alkalimetry in Non-aqueous Titrations— titration of acidic substances 6. A potentiometric titration method in non-aqueous media is proposed for the determination of some commonly used anti-inflammatory agents. The direct potentiometric titration of three anti-inflammatory agents, namely mefenamic acid, fenbufen and ibuprofen; and the indirect potentiometric titration of diclofenac sodium was carried out in acetonitrile solvent using tetra-n-butylammonium hydroxide. The Karl Fischer titration for water content is another nonaqueous titration, usually done in methanol or sometimes in ethanol. These assays sometimes take some perfecting in terms of being able to judge the endpoint precisely. Assay of chloroquine by non aqueous titration Nonaqueous titration - Wikipedia, Non aqueous titration - Aralen animeWhen hydroxychloroquine treatment rheumatoid arthritisPill plaquenil generic dog bone shapedHow to test chloroquine drug With. The method permits a rapid determination of different types of compounds common in the pharmacy of today amines and heterocyclic nitrogen compounds, amino-acids, alkali and organic salts of weak acids and of hydrogen halides. Acetic acid is the solvent most commonly used in the non-aqueous titration of bases. The fundamental work on the method was carried out NON-AQUEOUS ACID-BASE TITRATIONS IN PHARMACEUTICAL ANALYSIS. The non-aqueous titrimetric assay of the selected anti.. PDF Non-Aqueous Titrimetric Assay for Determination of.. Thus the choice of the appropriate medium and titrant permits the determination of a variety of such materials by non-aqueous titration. Further, depending upon which part of a compound is physiologically active, it is often possible to titrate that part by proper selection of solvent and titrant. Reported for the assay of CQP in dosage forms. An acid-base titrimetric method was developed, where the drug was titrated with 0.1 M NaOH in MeCN H2O medium using thymol blue as indicator 4. A non-aqueous titrimetric method involoving conductometric titration of drug with HClO 4 has also been reported 5. Gravimetric Non aqueous titration refers to a type of titration in which the analyte substance is dissolved in a solvent which does not contain water. This procedure is a very important one in pharmacopoeial assays. Non Aqueous Titration Theory. The need for non aqueous titration arises because water can behave as a weak base and a weak acid as well, and can hence compete in proton acceptance or proton.