License: CC BY 2.5Treatment of malaria is aimed at killing the schizonts by one or more mechanisms. Resistance occurs when the parasite develops mechanisms that reduce the effects of the antimalarials or bypasses the mechanisms of the drug. Is plaquenil an nsaid drug Plaquenil prototype The mechanism behind the plasmodicidal action of chloroquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit the heme polymerase activity, resulting in an accumulation of free heme, which is toxic to the parasites. Mechanism of action Quinine acts as a blood schizonticide although it also has gametocytocidal activity against P. vivax and P. malariae. Because it is a weak base, it is concentrated in the food vacuoles of P. falciparum. Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole. The mechanism of this blockade has not been established. Monotherapy should be avoided to prevent drug considered a superior antimalarial drug to quinine. Effects of the antimalarial drug primaquine on the dynamic structure of lipid model membranes. The American journal of tropical medicine and hygiene, 77(6 Suppl), 29–35. Resistance is a major problem in some parts of the world, e.g., Africa and Southeast Asia; therefore, newer drugs are utilized. Mechanism of action of chloroquine in malaria treatment Mechanisms of action of hydroxychloroquine and chloroquine., Antimalarial Drugs – Malaria Site Plaquenil mexicoVortex keratopathy hydroxychloroquine Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. Chloroquine - FDA prescribing information, side effects and uses. On the molecular mechanism of chloroquine's antimalarial action. Antimalarial medication - Wikipedia. Apr 02, 2019 Mechanism of Action. Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. Activity in vitro and in vivo Quick treatment of malaria infection is needed to prevent serious, possibly fatal, outcomes. When using chloroquine for treatment of malaria, tell your doctor if your condition persists or worsens. However, the fight against malaria becomes more difficult due to mosquitoes resistance to insecticides and Plasmodium falciparum strains which have developed increasing resistance to most of available antimalarial drugs. Chloroquine Nivaquine® was widely used as antimalarial drug and saved many lives for decades.