Goldberg SB1, Supko JG, Neal JW, Muzikansky A, Digumarthy S, Fidias P, Temel JS, Heist RS, Shaw AT, Mc Carthy PO, Lynch TJ, Sharma S, Settleman JE, Sequist LV. Erlotinib with or without hydroxychloroquine in chemo-naive advanced NSCLC and (EGFR) mutations. Boston, MA: National Library of Medicine (US): 2009-2015. Chikungunya arthritis hydroxychloroquine Chloroquine diphospahe bbguy Introduction The epidermal growth factor receptor EGFR inhibitor erlotinib is much less effective in non-small-cell lung cancer NSCLC tumors with wild-type EGFR, than in tumors with activating EGFR mutations. Autophagy is a tightly regulated lysosomal self-digestion process, which may alternatively promote cell survival or type II cell death. The autophagy inhibitor chloroquine overcomes the innate resistance of wild-type EGFR non-small-cell lung cancer cells to erlotinib. Journal of Thoracic Oncology 86 693-702. Link here 2. Autophagy is a regulated catabolic process triggered in cells deprived of nutrients or growth factors that govern nutrient uptake. Here, we report that autophagy is induced by cetuximab, a therapeutic antibody that blocks epidermal growth factor receptor function. Cancer cell treatment with cetuximab triggered autophagosome formation, conversion of microtubule-associated protein 1 light chain. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Since the pivotal trial evaluating the effect of temozolomide (TMZ), overall survival has not increased. National Insitute of Health; Massachusetts General Hospital. Chloroquine egfr Reactivation of Mutant-EGFR Degradation through Clathrin., Repurposing Drugs 101 - Chloroquine & Lung Cancer Does plaquenil cause dizziness the longer you take itChloroquine cataractHydroxychloroquine withdrawal symptoms Epidermal growth factor receptor tyrosine kinase inhibitors EGFR-TKIs, including gefitinib, are effective for non-small cell lung cancer NSCLC patients with EGFR mutations. However, these patients eventually develop resistance to EGFR-TKI. The goal of the present study was to investigate the involvement of autophagy in gefitinib resistance. Chloroquine Enhances Gefitinib Cytotoxicity in Gefitinib.. The Epidermal Growth Factor Receptor Antibody Cetuximab.. Chloroquine Is a Zinc Ionophore - PubMed Central PMC. Treatment of GBM xenografts in vivo with chloroquine CQ, an antimalarial agent, has been shown to reduce the hypoxic fraction and sensitizes tumors to radiation. Epidermal growth factor receptor EGFR amplification or mutation is regularly observed GBM and is thought to be a major contributor to radioresistance. Chloroquine Nivaquine was the first drug used for the treatment of malaria. It is effective against the blood stages of the malaria parasite and penetrates into most tissues. It is effective against Plasmodium ovale and malaria and susceptible strains of vivax and falciparum. Glioblastoma patients indicated that chloroquine treatment improves survival of all glioblastoma patients, but patients with EGFRvIII + glioblastoma beneﬁted most. Our ﬁndings disclose the unique autophagy dependency of EGFRvIII + glioblastoma as a therapeutic opportunity.