It seems as though it has helped the first two symptoms, but I have horrible constipation. Lots of people experience some GI issues when starting Plaquenil, but they usually subside after a short time. I have tried everything- I exercise every day, drink a ton of water, eat fiber like it’s going out of style, follow a gluten-free diet, take stool softeners after every meal and Miralax before bed at night. Did you start Plaquenil when you rec'd your diagnosis and did the constipation begin at the same time? Plaquenil suddenly stopping and mania Hydroxychloroquine plaquenil for rheumatoid arthritis My question Do you feel like you've gained weight on Plaquenil ie without Prednisone? The Plaquenil drug side effects list weight loss, but some people have reported weight gain instead. What's happened with you? My rheumy wants me to come down and then off my Plaquenil, but I've been resisting simply because I'm afraid to. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Aug 14, 2017 Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. I have intermittent problems with constipation and take Miralax at times - and feel that it sometimes causes bloating. I have really bad cramping, gas and it looks like I’m 7 months pregnant at times! I think it might be possible that the constipation could have something to do with the Lupus, as it can affect the GI tract also. Bad side effects of hydroxychloroquine Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Hydroxychloroquine Side Effects, Dosage, Uses, and More Chloroquine-induced pigmentation Serious Side Effects of Plaquenil. If you are taking Plaquenil long-term, such as for an autoimmune condition, your doctor should regularly check you for potential serious side effects. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. The Risk of Retinal Toxicity with Plaquenil. Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. Plaquenil Side Effects by Likelihood and Severity INFREQUENT side effects. If experienced, these tend to have a Severe expression. A Disorder Of The Retina Of The Eye;. RARE side effects. What are the possible side effects of hydroxychloroquine? Side effects are uncommon; however, a few people may develop a rash, indigestion, diarrhoea, headache, blurred vision, darkening of the skin, or bleaching of the hair. Hydroxychloroquine can aggravate pre-existing psoriasis. Does hydroxychloroquine affect fertility or pregnancy?