Chloroquine mechanism of action in rheumatoid arthritis

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  1. cheboor Well-Known Member

    Chloroquine mechanism of action in rheumatoid arthritis


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

    Chloroquine diphosphate salt autophagy Plaquenil retinopathy images Plaquenil and watery eyes Plaquenil side effects on heart

    It is a prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. PubChemThe mechanism of plasmodicidal action of chloroquine is not completely certain. Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and chloroquine in the treatment of rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory rheumatic diseases, insights into the mechanism of action of these drugs are still emerging. DIAGNOSTIC criteria for rheumatoid arthritis 1958 revision by a committee of the American Rheumatism Association. Ann Rheum Dis. 1959 Mar; 18 149–53. PMC free article Sams WM. Jr Chloroquine mechanism of action. Mayo Clin Proc. 1967 May; 42 5300–309. Shaw MW. Human chromosome damage by chemical agents.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine mechanism of action in rheumatoid arthritis

    Mechanism of action of hydroxychloroquine as an antirheumatic drug., Mechanisms of action of hydroxychloroquine and chloroquine.

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  5. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth.

    • Hydroxychloroquine - Wikipedia.
    • Action of chloroquine phosphate in rheumatoid arthritis..
    • Mechanism of action of hydroxychloroquine as an antirheumatic..

    Apr 10, 2019 Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Blood levels of racemic chloroquine and its main metabolites desethylchloroquine and bisdesethylchloroquine were measured in 29 patients treated chronically for rheumatoid arthritis. In six patients, the concentrations were followed during a one day dosage interval. There was considerable intersubject variability in the steady state blood concentrations of chloroquine range 36.6 to 3895 ng. Hydroxychloroquine is an antimalarial agent that has been used in systemic lupus erythematosus and rheumatoid arthritis treatment for many years. Recently, novel mechanisms of action have been proposed, thereby broadening the therapeutic perspective of this medication.

     
  6. drakmor Well-Known Member

    Since being diagnosed with Lupus and taking the normal meds, particularly Plaquenil and Prednisone (over about 6 years), I gained about 45 pounds. HYDROXYCHLOROQUINE - ORAL Plaquenil side effects, medical. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Can Plaquenil cause Increased Appetite? - Treato
     
  7. Dgerri Well-Known Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Remdesivir and chloroquine effectively inhibit the. Chloroquine - FDA prescribing information, side effects and uses Aralen chloroquine Malaria Drug Side Effects & Dosage
     
  8. gabdullin New Member

    Plaquenil Side Effects on Your Eyes and Vision Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. While today it is used to treat autoimmune conditions, such as rheumatoid arthritis and lupus, it was originally used as an anti-malaria drug.

    Hydroxychloroquine and the eye an old unsolved problem
     
  9. samandar New Member

    Hydroxychloroquine Sulfate Monograph for Professionals. Antimalarial; 4-aminoquinoline derivative. 109 Uses for Hydroxychloroquine Sulfate Malaria. Prevention prophylaxis of malaria caused by Plasmodium malariae, P. ovale, chloroquine-susceptible P. vivax, and chloroquine-susceptible P. falciparum. 109 115 Alternative when chloroquine is unavailable. 115 121 134

    Chloroquine sulfate salt 132-73-0 Reference standards.