It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Aralen contraindications 2016 ophthalmology journal hydroxychloroquine Reviews and ratings for sulfasalazine when used in the treatment of rheumatoid arthritis. 51 reviews submitted. I been on it for about a month, now. But not taking it anymore, been unable to go to work for 3 days now.run run - do not take - it is too much,". "I started taking sulfasalazine SZS with Plaquenil 2 months ago for RA. My mum was started on sulfasalazine 4 weeks ago for RA with severe bilateral hand pain and swelling. Initially everything was fine but when the dose was increased in the 2nd week to 500mg twice a day her mood started to deteriorate and developed symptoms of plantar fascitis. Plaquenil hydroxychloroquine is considered an older DMARD disease modifying anti-rheumatic drug. Plaquenil was actually first classified as an antimalarial drug, but it is also used to treat certain rheumatic and autoimmune conditions which are unrelated to malaria. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. What to use when plaquenil and sulfasalazine doesn't work Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus., Sulfasalazine User Reviews for Rheumatoid Arthritis at Hydroxychloroquine sulfate rashCan hydroxychloroquine stop osseointegrationWhat does chloroquine do in transfectionHydroxychloroquine in lupus nephritisPhototherapy and plaquenil combination Work closely with your doctor to find the best treatment for you. Eye damage can be a side effect of hydroxychloroquine. Sulfasalazine may cause allergic reaction if you are sensitive to sulfa. Rheumatoid Arthritis Drug Treatments Pros and Cons.. Taking Plaquenil for Rheumatoid Arthritis. Plaquenil and sulfasalazine - Autoimmune Disorders - MedHelp. I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems. Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you. Hydroxychloroquine doesn’t work immediately. It may be 12 weeks or longer before you notice any benefit. Because it's a long-term treatment it's important to keep taking hydroxychloroquine unless you have severe side-effects even if it doesn't seem to be working at first; even when your symptoms improve to help keep the disease under.