It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Plaquenil and alcohol use Is plaquenil administered subcutaneously Plaquenil pharmacology Chloroquine dose in tropical splenomegaly Hydroxychloroquine Plaquenil and generics can itself cause fatigue in some users, it can interrupt sleep patterns especially by causing more vivid dreams which in turn makes one more tired. The drug can also lower blood counts red cell, white cells and others too which in turn can cause fatigue. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Description and Brand Names. Drug information provided by IBM Micromedex US Brand Name. Plaquenil; Descriptions. Hydroxychloroquine is used to treat malaria. It is also used to prevent malaria infection in areas or regions where it is known that other medicines eg, chloroquine may not work. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Does plaquenil make you tired Plaquenil is being used to treat Covid 19 lupus, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil side effects on heart Sleep problems can increase levels of stress hormones and aggravate flares, says Rochelle Rosian, MD, a Cleveland Clinic rheumatologist. And even if you’re not flaring, you may not manage your pain as well if you’re not sleeping. “When you sleep, you make all those brain chemicals that you need to feel better. Rheumatoid Arthritis and Sleep Arthritis Foundation. Hydroxychloroquine Oral Route Description and Brand.. Taking Plaquenil for Rheumatoid Arthritis. Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects. Hydroxychloroquine is a good drug for mild arthritis however length of time it takes for drug to leave body is worrying when you are faced with loosing your sight and possible progression after you stopped taking the drug. Also check the dose is correct for your ideal weight do you are not over medicated." Is extreme fatigue a side effect of Plaquenil? Support Forums. a nap during the day. I don't know if this is just the way RA is, or if it is a side effect of the medicine. I wake up tired in the morning, get my kids fed and off to the schoolbus, and some days that's all I can do until it's time to go pick them up and make dinner, then I.